In Missouri, between 1981 and 2010 the average date at which trees first showed their leaves was two days earlier than the average between 1951 and 1980, according to this graphic by Climate Central.
You’ll also note the north-south trend, where change is greater as you go north. Most models predict that global warming/climate change due to increasing carbon dioxide will result in bigger changes as you get toward the poles.
The map is based on data from the National Phenology Network. The National Phenology Network has a good educational resource page, as well as access to their datasets.